A Case of Generalized Lichen Planus Cured by Griseofulvin.
- Author:
Sung Hoon LEE
;
Soon Baek KWON
;
Sang Lip CHUNG
;
Do Won KIM
;
Jae Bok JUN
- Publication Type:Case Report
- Keywords:
Lichen planus;
Griseofulvin
- MeSH:
Adrenal Cortex Hormones;
Anti-Bacterial Agents;
Antimalarials;
Biopsy;
Cyclophosphamide;
Cyclosporine;
Dapsone;
Griseofulvin*;
Humans;
Hyperpigmentation;
Lichen Planus*;
Lichens*;
Male;
Methotrexate;
Middle Aged;
Recurrence;
Retinoids;
Skin
- From:Korean Journal of Dermatology
1999;37(3):371-375
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although a number of remedies like corticosteroids, retinoids, griseofulvin, PUVA, cyclosporine, antibiotics, dapsone, cyclophosphamide, surgery, methotrexate, radiation therapy, antimalarial drugs, psychotharapy and psychiatric medications have been used to treat lichen planus, there were no specific methods until now. We report herein an interesting case of lichen planus in which complete healing was achieved by griseofulvin administration. The patient was a 54-year-old male who for 3 months had variouly sized and shaped, flat-topped, scaly, violaceous papules and plaques on the whole of his body. We confirmed the patients disease as lichen planus by a histopathologic examination of a skin biopsy specimen and gave him 500mg ultramicronized griseofulvin daily in divided dosages. After 12 weeks of the medication nearly all of the skin lesions were regressed, and by 14 weeks all skin lesions had disappeared leaving hyperpigmentation. Up to now, l9 months after discontinuation of the medication, no recurrence of the disease has been noted.
