T cell Proliferative Response to Type II collagen is related to Inflammatory Process and Joint Damage in Rheumatoid Arthritis.
- Author:
Jin Jung CHOI
1
;
Wan Uk KIM
;
Mi La CHO
;
Myeung Su LEE
;
Young Il SEO
;
Do June MIN
;
Sung Hwan PARK
;
Chul Soo CHO
;
Ho Youn KIM
Author Information
1. Institute of Immunobiology in Catholic Research Institutes of Medical Science, School of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. rheuma@cmc.cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Rheumatoid arthritis;
type II collagen;
T cells;
inflammatory activity;
radiographic progressio
- MeSH:
Arthritis, Rheumatoid*;
Blood Sedimentation;
C-Reactive Protein;
Collagen Type II*;
Cross-Sectional Studies;
Disease Progression;
Hand;
HLA-DR1 Antigen;
Humans;
Joints*;
Lymphocytes;
T-Lymphocytes
- From:The Journal of the Korean Rheumatism Association
2002;9(2):106-116
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the role of T cell responses to type II collagen (CII) in disease progression in rheumatoid arthritis (RA). METHODS: T cell proliferative responses to bovine CII by peripheral blood mononuclear cells (PBMC) from early RA patients (duration <5 years) were assayed by mixed lymphocyte culture. Clinical and laboratory variables including erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) were examined at the time of sampling. Radiographic damage on hand X-rays was evaluated by the method of Steinbrocker and Sharp. RESULTS: In a cross-sectional study, patients (n=22) with positive T cell responses (stimulation index: SI>or =2) had higher levels of CRP and ESR than those (n=21) not showing T cell responses. The number of damaged joints (by Steinbrocker's method) and damaged joint scores (by Sharp's method) were significantly higher in patients with positive T cell responses than in those without. The joint space narrowing scores correlated well with T cell responsiveness to CII. Patients (n=15) with both positive T cell responses and RA-susceptible allotypes, HLA-DR1 or DR4, had greater damaged joint scores than the rest of patients (n=24). CONCLUSION: T cell proliferative responses to CII are associated with inflammatory activity and radiographic severity in RA. Our data suggest that CII reactive T cells may play an important role in the pathogenic process of joint damage.
