Extracorporeal Therapy as a Treatment Method in Patients with Acute Ethylene Glycol Poisoning.
- Author:
Jae Woo SONG
1
;
Sang Chun CHOI
;
Samsun LAMPOTANG
;
Young Gi MIN
;
Yoon Seok JOUNG
Author Information
1. Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea. avenue59@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Ethylene glycol;
Poisoning;
Renal replacement therapy
- MeSH:
Acid-Base Equilibrium;
Acute Kidney Injury;
Animals;
Blood Gas Analysis;
Comb and Wattles;
Diagnosis;
Eating;
Ethanol;
Ethylene Glycol*;
Glycols;
Humans;
Hydrogen-Ion Concentration;
Intention;
Length of Stay;
Methods*;
Plasma;
Poisoning*;
Renal Replacement Therapy;
Retrospective Studies
- From:Journal of the Korean Society of Emergency Medicine
2017;28(1):109-116
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Extracorporeal treatment has been used increasingly to treat patients with acute ethylene glycol poisoning. We analyzed all patients with acute poisoning of ethylene glycol during a recent 10-year period to provide clinical recommendations for adequate application of continuous renal replacement therapy for these patients. METHODS: A retrospective chart review study was conducted for patients whose final diagnosis were “toxic effects of glycols or other alcohols,” between October 2006 and September 2016. The basal characteristics of patients, suspected amount of ingestion, intention of poisoning, concomitant alcohol ingestion, mental state at admission, time from exposure to admission, chief complaint, length of hospital stay, method of treatments, laboratory results including acute kidney injury and urine oxalate crystal, as well as treatment results were examined. RESULTS: A total number of 14 patients were included in this study. Nine patients (64.3%) underwent continuous renal replacement therapy; 5 patients (35.7%) underwent ethanol mono-therapy. Between the antidote therapy group and the extracorporeal treatment group, there was a significant difference in the levels of plasma bicarbonate, chloride, anion gap, pH, and base excess in arterial blood gas analysis, as well as the calculated osmolar gap. One patient expired due to multi-organ failure, while the others recovered completely. CONCLUSION: Continuous renal replacement therapy was most frequently chosen as a treatment method in patients with acute ethylene glycol poisoning. Further research regarding indication of continuous renal replacement therapy and combing therapy with other treatment will be necessary to determine the best treatment method.
