Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients.
10.4093/dmj.2011.35.5.536
- Author:
Sunghwan SUH
1
;
Hyung Doo PARK
;
Se Won KIM
;
Ji Cheol BAE
;
Alice Hyun TAN
;
Hye Soo CHUNG
;
Kyu Yeon HUR
;
Jae Hyeon KIM
;
Kwang Won KIM
;
Moon Kyu LEE
Author Information
1. Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. leemk@skku.edu
- Publication Type:Original Article
- Keywords:
Coronary heart diseases;
Diabetes mellitus;
LDL particle size;
Small dense low density lipoprotein
- MeSH:
Acrylic Resins;
Body Mass Index;
Carotid Stenosis;
Constriction, Pathologic;
Coronary Artery Disease;
Coronary Disease;
Diabetes Mellitus;
Diabetes Mellitus, Type 2;
Electrophoresis;
Heart;
Humans;
Hypertriglyceridemia;
Lipoproteins;
Myocardial Infarction;
Particle Size;
Risk Factors;
Stroke
- From:Diabetes & Metabolism Journal
2011;35(5):536-542
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Small dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease. METHODS: The mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-documented coronary artery disease or a myocardial infarction. Peripheral vascular stenosis, carotid artery stenosis (> or =50% in diameter) or carotid artery plaque were considered minor vascular complications. Overall vascular complications included both major and minor vascular complications. RESULTS: Diabetic patients had significantly smaller mean-LDL particle size (26.32 nm vs. 26.49 nm) and a higher percentage of sdLDL to total LDL compared to those of subjects without diabetes (21.39% vs. 6.34%). The independent predictors of sdLDL in this study were serum triglyceride level and body mass index (odds ratio [OR], 1.020 with P<0.001 and OR 1.152 with P<0.027, respectively). However, no significant correlations were found between sdLDL and major vascular complications (P=0.342), minor vascular complications (P=0.573) or overall vascular complications (P=0.262) in diabetic subjects. CONCLUSION: Diabetic patients had a smaller mean-LDL particle size and higher proportion of sdLDL compared to those of subjects without diabetes. Obese diabetic patients with hypertriglyceridemia have an increased risk for atherogenic small dense LDL. However, we could not verify an association between LDL particle size and vascular complications in this study.
