A Paragonimiasis Patient with Allergic Reaction to Praziquantel and Resistance to Triclabendazole: Successful Treatment after Desensitization to Praziquantel.
- Author:
Sun Young KYUNG
1
;
Yong Kyun CHO
;
Yu Jin KIM
;
Jeong Woong PARK
;
Sung Hwan JEONG
;
Jae Ik LEE
;
Yon Mi SUNG
;
Sang Pyo LEE
Author Information
- Publication Type:Case Report
- Keywords: Paragonimus; paragonimiasis; praziquantel; triclabendazole; drug allergy; desensitization
- MeSH: Animals; Benzimidazoles/*therapeutic use; *Desensitization, Immunologic; Drug Hypersensitivity/etiology/immunology/*therapy; *Drug Resistance; Female; Humans; Middle Aged; Paragonimiasis/*drug therapy/immunology/parasitology; Paragonimus/isolation & purification/physiology; Praziquantel/*adverse effects/*immunology/therapeutic use; Treatment Outcome
- From:The Korean Journal of Parasitology 2011;49(1):73-77
- CountryRepublic of Korea
- Language:English
- Abstract: Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.
