A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy.
- Author:
Seung Seog KI
1
;
Jin Mo JEONG
;
Seong Ho KIM
;
Sook Hyang JEONG
;
Jin Hyuk LEE
;
Chul Ju HAN
;
You Cheol KIM
;
Jhin Oh LEE
;
Young Joon HONG
Author Information
1. Department of Internal Medicine Korea Cancer Center Hospital, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Fluorouracil;
Neuorotoxicity syndromes;
Leukoencephalopathy, progressive multifocal
- MeSH:
Adult;
Brain/*pathology;
Case Report;
Electroencephalography;
Fluorouracil/*adverse effects/therapeutic use;
Gastrointestinal Neoplasms/drug therapy;
Human;
Leukoencephalopathy, Progressive Multifocal/diagnosis/etiology;
Magnetic Resonance Imaging;
Male;
Neurotoxicity Syndromes/diagnosis/*etiology
- From:The Korean Journal of Internal Medicine
2002;17(1):73-77
- CountryRepublic of Korea
- Language:English
-
Abstract:
5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gast- rointestinal stromal tumor. 5-FU-induced neurotoxicity should, therefore, be considered as an important differential diagnosis in cancer patients with neurological abnormality and history of chemotherapy.
