The Effect of 1-Propanol on the Rotational Mobility of n-(9-Anthroyloxy) stearic acid in Outer Monolayers of Neuronal and Model Membranes.
10.11620/IJOB.2017.42.4.175
- Author:
Tae Young AHN
1
;
Seong Deok JIN
;
Hak Jin YANG
;
Chang Dae YOON
;
Mi Kyung KIM
;
Taek Kyung AN
;
Young Jun BAE
;
Sang Jin SEO
;
Gwon Su KIM
;
Moon Kyoung BAE
;
Soo Kyoung BAE
;
Hye Ock JANG
Author Information
1. Department of Dental Pharmacology and Biophysics, School of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, Yangsan 626-870, South Korea. jho9612@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
1-propanol;
Fluorescence quenching technique;
Rotational mobility;
Hydrocarbon interior;
Membranes interface
- MeSH:
1-Propanol*;
Carbon;
Cell Membrane;
Cerebral Cortex;
Ethanol;
Hydrocarbons;
Liposomes;
Membranes*;
Neurons*;
Phospholipids
- From:International Journal of Oral Biology
2017;42(4):175-181
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to provide a basis for the molecular mechanism underlying the pharmacological action of ethanol. We studied the effects of 1-propanol on the location of n-(9-anthroyloxy)palmitic acid or stearic acid (n-AS) within the phospholipids of synaptosomal plasma membrane vesicles (SPMV). The SPMV were isolated from the bovine cerebral cortex and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL). 1-Propanol increased the rotational mobility of inner hydrocarbons, while decreasing the mobility of membrane interface, in native and model membranes. The degree of rotational mobility varied with the number of carbon atoms at positions 16, 12, 9, 6 and 2 in the aliphatic chain of phospholipids in the neuronal and model membranes. The sensitivity of increasing or decreasing rotational mobility of hydrocarbon interior or surface by 1-propanol varied with the neuronal and model membranes in the following order: SPMV, SPMVPL and SPMVTL.
