Congenital Melanocytic Nevus Showing an Unusual Clinical Manifestation.
- Author:
You Jin YANG
1
;
Yoon Hwan KIM
;
Joon LEE
;
Dong Hoon KIM
;
Hee Jung KIM
;
Ga Young LEE
;
Won Serk KIM
Author Information
1. Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. heejung46.kim@samsung.com
- Publication Type:Case Report
- Keywords:
Congenital melanocytic nevus;
Neurofibroma;
Neurotized nevus
- MeSH:
Biopsy;
Dermis;
Female;
Glial Fibrillary Acidic Protein;
Hemangioma;
Humans;
Neurofibroma;
Nevus;
Nevus, Pigmented;
Skin;
Young Adult
- From:Korean Journal of Dermatology
2011;49(7):648-651
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Completely neurotized melanocytic nevi are often clinically and histologically indistinguishable from neurofibromas. We report a 23-year-old female who presented with a dark brown plaque with an underlying soft blue subcutaneous nodule in the left infra-axillary area. The skin biopsy revealed markedly increased melanocytic proliferation and nests of nevus cells within dermo-epidermal junction and upper dermis. Circumscribed, non-encapsulated tumor of the dermis was composed of loosely-spaced spindle cells and wavy stroma. Spindle cells in the lower dermis showed staining for S-100, but failed to express glial fibrillary acidic protein and Leu-7. We present an interesting case because the lesion presented as a soft blue subcutaneous nodule suggested an underlying hemangioma or neurofibroma initially, but was shown to be a neurotized melanocytic nevus based on immunohistochemical examination.
