Histiocyte-Rich Reactive Lymphoid Hyperplasia of the Liver: Unusual Morphologic Features.
10.3346/jkms.2008.23.1.156
- Author:
Ho Sung PARK
1
;
Kyu Yun JANG
;
Young Kon KIM
;
Baik Hwan CHO
;
Woo Sung MOON
Author Information
1. Department of Pathology, Chonbuk National University, Medical School, Institute for Medical Sciences and the Center for Healthcare Technology Development, Jeonju, Korea. mws@chonbuk.ac.kr
- Publication Type:Case Report ; Review
- Keywords:
Pseudolymphoma;
Liver Neoplasms;
Lymphoid Hyperplasia, Reactive
- MeSH:
Carcinoma, Renal Cell/pathology;
Female;
Histiocytes/*pathology;
Humans;
Kidney Neoplasms/pathology;
Liver Diseases/*pathology;
Middle Aged;
Pseudolymphoma/*pathology
- From:Journal of Korean Medical Science
2008;23(1):156-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
Reactive lymphoid hyperplasia (RLH) of the liver is a rare entity and has also been termed nodular lymphoid lesion or pseudolymphoma of the liver. We report a case of hepatic RLH exhibiting unusual histiocyte-rich histologic features in a 47-yr-old woman in conjunction with a renal cell carcinoma. A follow-up computed tomography scan was done 14 months after a right radical nephrectomy for renal cell carcinoma revealed a nodular lesion in segment 5 of the liver. The lesion was interpreted as metastatic renal cell carcinoma or hepatocellular carcinoma based on the history of the patient and radiologic findings. Wedge resection of segment 5 was done with sufficient distance from the mass. Microscopically, the lesion was composed predominantly of peculiar histiocytic proliferation and was characterized by lymphoid aggregates forming a lymphoid follicle with germinal centers. The present case and prior cases reported in the literature suggest that RLH of the liver appear to be a heterogenous group of reactive inflammatory lesions that are often associated with autoimmune disease or malignant tumors.
