Availability of Blood Urea Nitrogen/Creatinine Ratio in Gastrointestinal Bleeding with Melena in Children.
10.5223/pghn.2015.18.1.30
- Author:
Kyu Seon KIM
1
;
Chan Ho KANG
;
Jae Young KIM
Author Information
1. Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, Korea. pedkim@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
Gastrointestinal;
Bleeding;
Melena;
Child
- MeSH:
Blood Urea Nitrogen;
Child*;
Creatinine;
Demography;
Hemorrhage*;
Humans;
Meckel Diverticulum;
Melena*;
Peptic Ulcer;
Retrospective Studies;
Urea*;
Varicose Veins
- From:Pediatric Gastroenterology, Hepatology & Nutrition
2015;18(1):30-38
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aims of our study were to evaluate the blood urea nitrogen to creatinine ratio (BUN/Cr ratio) for distinguishing between an upper and lower gastrointestinal bleeding (GIB), and differentiating between the two most common causes of upper gastrointestinal bleeding (UGIB) presenting with melena in children. METHODS: Retrospective data of patients with GIB presenting with melena were analyzed. The data from 60 cases were reviewed including demographics, laboratory findings, diagnostic modalities and results, treatments, and transfusions. RESULTS: Among the 60 cases, UGIB and lower gastrointestinal bleeding (LGIB) were found in 35 cases (58.3%) and 14 cases (23.3%), respectively. The two common causes of UGIB were varices (37.1%), and peptic ulcer diseases (PUD) (31.4%). The BUN/Cr ratio of 30 or greater was higher in UGIB than LGIB (odds ratio [OR], 6.9; 95% confidence interval [95% CI], 1.3-37.2). In UGIB, the BUN/Cr ratio of the varices group was higher than that of the PUD group (p=0.015). The OR for the BUN/Cr ratio appeared as 1.2 per unit increase in the varices group than the PUD group (95% CI, 1.03-1.3). There was no difference between the PUD group and Meckel's diverticulum group. CONCLUSION: The BUN/Cr ratio was not uneven in differentiating UGIB from LGIB of children with melena in our study. This suggests that BUN/Cr ratio should be interpreted carefully.
