The Study on Stability of Fibronectin Eyedrops.
- Author:
Tae Jin KIM
1
;
Jae Chan KIM
;
Bon Sool KOO
Author Information
1. Department of Ophthalmology, College of Medicine, Chung-Ang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Fibronectin;
Biological activity
- MeSH:
Extracellular Matrix;
Fibronectins*;
Glycoproteins;
Humans;
Ophthalmic Solutions*;
Plasma;
Ulcer;
Wound Healing
- From:Journal of the Korean Ophthalmological Society
1990;31(3):265-271
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fibronectin, a kind of glycoprotein, which is present in human plasma and extracellular matrix, has been reported to facilitate wound healing on various corneal disorders such as trophic ulcer and recurrent corneal erosion. In this experimental study, we observed how the temperature, duraion of storage and concentration of fibronectin effect its biological activity. The temperature, duration of storage and concentration of fibronectin were correlated to biological activity statistically(p<0.05). The temperature of storage had a great influence to biological activity. When stored at 4degreeC, the biological activity was well maintained up to 2 weeks, but the biological activity had dropped suddenly after the 3rd day when it was stored at 35 degrees C. This result suggested that fibronectin eyedrop had the decreasing effect as the stored temperatre rises and the stored duration increases, therefore it is recommended that fibronection eyedrop must be made fresh every two weeks and be stored at 4 degrees C.
