Extracellular Matrix in Human Trabecular Meshwork.
- Author:
Il Won PARK
1
;
Myung Kyoo KO
;
Joon Kiu CHOE
Author Information
1. Department of Ophthalmology, School of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
extracellular matrix;
fibronectin;
trabecular meshwork;
type IV collagen
- MeSH:
Antibodies, Monoclonal;
Basement Membrane;
Collagen Type IV;
Extracellular Matrix*;
Fibronectins;
Humans*;
Microscopy;
Rupture;
Trabecular Meshwork*
- From:Journal of the Korean Ophthalmological Society
1990;31(3):297-301
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was performed to evaluate the distribution of extracellular matrix in the normal human trabecular meshwork. The trabecular meshworks obtained from 5 enucleated eyes due to traumatic eye-ball rupture were frozen processed, stained with monoclonal antibodies for fibronectin and type IV collagen, and observed by fluorescent microscopy. The indirect immunofluorescent study showed strong positive reactions in the subendothelial basement membrane for fibronectin and type IV collagen and negative reaction in the central core of trabecular beam. These results suggest that fibronectin and type IV collagen distribute predominantly in the basement membrane of the trabecular beam.
