Xepoderma Pigmentosum Complicated by Squamous Cell Epithelioma and its Treatment with Bleomycin.
- Author:
Poong Myung KIM
;
Jae Ik HONG
;
Soo Duk LIM
- Publication Type:Original Article
- MeSH:
Bleomycin*;
Carcinoma*;
Dermatology;
Fibrosarcoma;
Keratoacanthoma;
Korea;
Skin Diseases;
Skin Neoplasms;
Ulcer;
Xeroderma Pigmentosum
- From:Korean Journal of Dermatology
1971;9(2):35-40
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Xeroderma pigmentosum, a rare, genetically determined dermatosis, is often cornplicated by malignant chagnes of various types-most commonly, basal-cell epithelioma, squamous cell epithelioma, less frequently malignant meIanoma, keratoacanthoma, fibrosarcoma, and endothelioma have been reported. In Korea, no case has ever been reported in literature except four cases at a symposium for dermatology, two of them complicated by basal-cell epithelioma, and the others by squamous cell epithelioma. This case reported was complicated by squamous cell epithelioma. As one of the anticancer treatments, especially for skin cancer, Bleomycin is, now, drawing the attention for its high therapeutic index with only few side effects. For this case, we injected Rleomycin 15mg at once, twice a week, for 8 weeks, So total injection was 16 times and 240mg of Bleomycin was given in total. While this amount given for this case was not enough for the complete treatment of squamous cell epithelioma, we got the following results: 1. Clinically, the ulcerated lesion of the cancer on the right ala nasi had shrunken in size with reepithelialization at the margin showing clear surface, and 2. microscopically, the atypical cancer cell masses and individual cell keratinizations had been decreased in size and in number, and less remarkable comparing to those in untreated stage at his first visit to the hospital.
