Eosinophils and Type 2 Cytokine Signaling in Macrophages Support the Biogenesis of Cold-induced Beige Fat.
- Author:
Yunjae JUNG
1
Author Information
- Publication Type:Brief Communication
- Keywords: Brown adipose tissue; Beige fat; Thermogenesis; Eosinophil; Type 2 cytokine
- MeSH: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Organelle Biogenesis*; Catecholamines; Cytokines; Eosinophils*; Fatty Acids; Homeostasis; Hot Temperature; Macrophages*; Thermogenesis
- From:Journal of Bacteriology and Virology 2016;46(1):44-46
- CountryRepublic of Korea
- Language:English
- Abstract: Brown adipose generates heat via oxidation of fatty acids by a mitochondrial uncoupling protein 1 (UCP1)-dependent process. In addition, a subpopulation of cells within subcutaneous white adipose tissue, known as beige adipocytes, also plays a role in thermogenesis. The biogenesis of beige adipocytes is induced by thermogenic signals, such as chronic cold exposure. Recently, it has been reported that eosinophils, type 2 cytokines of IL-4/13, and alternatively activated macrophages control the thermogenic cycle of beige adipocytes. Alternatively, activated macrophages induce UCP1+ beige adipocytes through secretion of catecholamines. These results define the role of type 2 immune responses in the regulation of energy homeostasis.
