Autoimmune Neuropsychiatric Disorder and Tic Symptom Exacerbation in Tourette's Disorder: Comparision of Treatment Modalities.
- Author:
Yoosook JOUNG
1
;
Yoonsun YANG
;
Moonhyang LEE
;
Hyo Jung KO
;
Youngki CHUNG
;
Hoyoung LEE
Author Information
1. Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Streptococcal infection;
Tourette's disorder;
Immune therapy
- MeSH:
Antipsychotic Agents;
Child;
Drug Therapy;
Humans;
Immunoglobulins, Intravenous;
Streptococcal Infections;
Streptococcus;
Tics*;
Tourette Syndrome*
- From:Journal of Korean Neuropsychiatric Association
2001;40(6):1204-1213
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECT: The purpose of this study was to investigate that infection with group A[beta] hemolytic streptococcus may associate the mechanisms that cause or exacerbate some cases of Tourette's disorder and to evaluate the treatment effect of IG therapy, comparing between IG therapy and drug therapy. METHOD: The subjects were divided into three groups composing of the groups with increasing level of ASO titer and the group with normal level of ASO titer, treating with antipsychotics. Children with infection-triggered exacerbation of Tourette's disorder were assigned treatment with IVIG (400mg/kg/daily on 5 consecutive days) or antipsychotic drugs. Symptom severity was rated at baseline, and at 4weeks, at at 8weeks after treatment by use of standard assessment scale of tics. RESULTS: 1) The motor tic score, global severity scores and overall TS impairment rating scores of YGTSS in the group with incresing level of ASO titer were related with ASO titer. 2) Immune therapy was more effective in the group with incresing level of ASO titer than antipsychotic drug therapy. CONCLUSION: These results suggest that increasing level of ASO titer, resulting from group A[beta] hemolytic streptococcal infection has affected worsening the tic symptoms in Touette's disorder and in group with increasing level of ASO titer, IVIG therapy is more effective than drug therapy.
