Myelodysplastic syndrome that progressed to acute myelomonocytic leukemia with eosinophilia showing peculiar chromosomal abnormality: a case report.
10.3346/jkms.1999.14.4.448
- Author:
Seong Ho KIM
1
;
Cheol Won SUH
;
Seong Jun CHOI
;
Jung Gyun KIM
;
Je Hwan LEE
;
Sung Bae KIM
;
Sang We KIM
;
Kyoo Hyung LEE
;
Jung Shin LEE
;
Woo Kun KIM
;
Sang Hee KIM
;
Eul Ju SEO
;
Hyun Sook CHI
Author Information
1. Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Myelodysplastic syndromes;
Leukemia, myelomonocytic, acute;
Eosinophilia;
Chromosome abnormalities
- MeSH:
Adult;
Anemia/pathology;
Anemia/genetics;
Anemia/etiology;
Bone Marrow/pathology;
Case Report;
Chromosomes, Human, Pair 16*;
Disease Progression;
Eosinophilia/pathology;
Eosinophilia/genetics*;
Eosinophilia/etiology;
Human;
Inversion (Genetics)*;
Karyotyping;
Leukemia, Myelocytic, Acute/pathology;
Leukemia, Myelocytic, Acute/genetics*;
Leukemia, Myelocytic, Acute/etiology;
Male;
Myelodysplastic Syndromes/pathology;
Myelodysplastic Syndromes/genetics*;
Myelodysplastic Syndromes/complications
- From:Journal of Korean Medical Science
1999;14(4):448-450
- CountryRepublic of Korea
- Language:English
-
Abstract:
Myelodysplastic syndrome is a closely related group of acquired bone marrow disorders characterized by ineffective and dysplastic hematopoiesis. These clonal disorders frequently progress to acute leukemia. Acute myelomonocytic leukemia with eosinophilia is characterized by an increase in abnormal eosinophils in the bone marrow, relatively good clinical course and inv (16) chromosomal abnormality. We experienced one case of refractory anemia with excess blasts which progressed to refractory anemia with excess blasts in transformation and finally to acute myelomonocytic leukemia with eosinophilia showing peculiar chromosomal abnormalities of der (1;7).
