Antihypertensive Effects and Safety of Manidipine in Patients with Essential Hypertension.
10.4070/kcj.1995.25.6.1234
- Author:
Won Ho LEE
;
Moo Yeol LEE
;
Kyung Hwan SON
;
Heung Sun KANG
;
Chung Whee CHOUE
;
Kwon Sam KIM
;
Myung Shick KIM
;
Jung Sang SONG
;
Jong Hoa BAE
- Publication Type:Original Article
- Keywords:
Hypertension;
Calcium channel blocker;
Manidipine
- MeSH:
Blood Pressure;
Calcium;
Calcium Channels;
Female;
Heart Rate;
Humans;
Hypertension*;
Muscle, Smooth;
Myocardial Ischemia
- From:Korean Circulation Journal
1995;25(6):1234-1240
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Calcium antagonists are highly effective agents for lowering high blood pressure and play a very important role in the treatment of Patient with ischemic heart disease and various other cardiovascular disorder. Manidipine, a dihydropyridine-type ccalcium channel blocker, is a potent relaxant of the arteriolar smooth muscle. We studied ths new calcium channel blocker to evaluated the efficacy and safety in patients with essectial hypertension. METHODS: Twenty patients(ten women and ten men;range of age, 30-66 years old)with mild-to-moderate essential hypertension were enrolled in this study. After a placebo run-in phase of two weeks duration, 5mg-20mg manidipine once daily orally was administered for eight weeks. RESULTS: 1) At the end of 8 weeks of manidipine therapy, systolic and diastolic blood pressure were significantly reduced from 160.1+/-11.8/105.5+/-5.1mmHG in sitting, 160.1+/-12.1/104.5+/-5.4mmHG in supine, 157.1+/-17.0/104.1+/-5.3mmHg in standing to 128.4+/-10.1/85.2+/-5.7mmHg in sitting, 129.1+/-10.2/84.2+/-5.9mmHg in supine, 128.1+/-12.8/86.7+/-5.9mmHg in standing(p<0.01). 2) The pulse rate did dnot change significantly. 3) The reduction of mean systolic and diastolic blood pressur at the end of 8 weeks were 31.5+/-14.5/20.3+/-7.4mmHg in sitting. 4) There was no serious side effect except mild symptom, mild headache(6 casem 30%) and facial flushing(1 case, 5%). CONCLUSION: These results indicate that manidipine is an effective and safe antihypertensive agent in the treatment of mild and moderate essential hypertension.
