Comparison of Hemostatic Effect of Endoscopic Injection with Fibrin Glue (FG) and Hypertonic Saline - epinephrine (HSE) for Peptic Ulcer Bleeding: A prospective randomized trial.
- Author:
Young Myung MOON
;
Jin Kyung KANG
;
In Suh PARK
;
Chae Yoon CHON
;
Jae Bock CHUNG
;
Kwang Hyub HAN
;
Won Ho KIM
;
Si Young SONG
;
Wook Hee WON
- Publication Type:Clinical Trial ; Original Article ; Randomized Controlled Trial
- Keywords:
Fibrin glue;
Hypertonic saline - epinephrine;
Endoscopic injection therapy;
Peptic ulcer bleeding
- MeSH:
Epinephrine*;
Fibrin Tissue Adhesive*;
Fibrin*;
Hemorrhage*;
Hemostasis;
Humans;
Necrosis;
Peptic Ulcer*;
Prospective Studies*
- From:Korean Journal of Gastrointestinal Endoscopy
1995;15(1):12-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Endoscopic injection therapy using various different agents(ethanol, polidocanol, epinephrine with and without hypertonic saline, etc.) is considered as the least expensive and effective technique to obtain hemostasis in peptic ulcer bleeding, however most of these agents induce tissue necrosis or degeneration. Theoretically the injection of fibrin glue in peptic ulcer bleeding may be safer than that of other agents, however, to date, there have been no data from randomized clinical trials on the comparison of the efficacies between these agents. To compare the hemostatic efficacy between FG[Beriplast P, Behring, Germany] and HSE[3% saline and epinephrine(1: 10,000)], we conducted a prospective, randomized, clinical trial among one hundred twenty-seven patients with peptic ulcer bleeding from March, 1992 to December, 1993 and in whom a visible vessel or active bleeding was identified.
