The Clinical Significance of Antibody Screening Test Including Di(a+) Panel Cell in Asian-Mongoloid Populations.
10.3346/jkms.2003.18.5.669
- Author:
Tae Sung PARK
1
;
Seung Hwan OH
;
Jae Cheol CHOI
;
Dae Dong LEE
;
Hyung Hoi KIM
;
Chulhun L CHANG
;
Eun Yup LEE
;
Han Chul SON
Author Information
1. Department of Laboratory Medicine, Pusan National University College of Medicine, Busan, Korea. hhkim@pusan.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Di(a) Antigen;
Blood Banks;
Ethnic Groups;
Anti-Di(a);
Antibody Screening Test
- MeSH:
Adult;
*Antibody Formation;
Asian Continental Ancestry Group;
Blood Banks;
Blood Group Antigens/*immunology;
Blood Grouping and Crossmatching;
Blood Transfusion;
Erythrocytes/immunology;
Female;
Human;
Immunologic Techniques;
Korea;
Male;
Middle Aged;
Support, Non-U.S. Gov't
- From:Journal of Korean Medical Science
2003;18(5):669-672
- CountryRepublic of Korea
- Language:English
-
Abstract:
The Di(a) antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. Thus, it has been speculated that the incidence of unexpected antibody against the Di(a) antigen might be relatively higher among these populations. Hemolytic transfusion reactions (HTRs) and hemolytic disease of the newborns (HDNs) caused by anti-Di(a) have been reported sporadically. However, there has been no prospective study on the incidence of anti-Di(a) in Mongoloid populations particularly. The authors conducted a series of antibody screening tests on 11,219 Korean individuals for 25 months, by using three kinds of screening cells including Di(a) cell. Anti-Di(a) was detected in 8 patients, seven of whom had a history of transfusions or were multigravida. The incidence of anti-Di(a) measured in this study was higher than expected, ranked third among unexpected antibodies identified during the period of the study, so it is strongly recommended that the Di(a+) panel cell must be incorporated into antibody screening test for safer transfusion in Asian-Mongoloid populations.
