Usefulness of a Pharmacokinetic Model Based on Dynamic Contrast-enhanced MRI for the Detection and Localization of Prostate Cancer.
10.3348/jkrs.2007.57.2.159
- Author:
Ae Kyung JEONG
1
;
Jeong Kon KIM
;
Kyoung Sik CHO
Author Information
1. Department of Radiology, Ulsan University Hospital, South Korea. rialto@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Prostate;
Magnetic resonance imaging (MRI);
Pharmacokinetics;
Prostatic neoplasms;
Neoplasm staging
- MeSH:
Humans;
Magnetic Resonance Imaging*;
Neoplasm Staging;
Perfusion;
Pharmacokinetics;
Prostate*;
Prostatectomy;
Prostatic Neoplasms*;
ROC Curve
- From:Journal of the Korean Radiological Society
2007;57(2):159-165
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the usefulness of a pharmacokinetic model based on dynamic contrast-enhanced (DCE) MR imaging for the detection and localization of prostate cancer. MATERIALS AND METHODS: Forty-four patients that had undergone radical prostatectomy for prostate cancer and dynamic contrast enhanced (DCE) MR imaging (slice thickness, 4 mm; time resolution of each set, 5 seconds), were enrolled in the study. From the pharmacokinetic model, the time of arrival, and the parameters Ah, Kep, and Kel were extracted and were compared for cancerous tissue and non-cancerous tissue in the central gland and peripheral zone. The diagnostic performance of each parameter for differentiating cancerous tissue from non-cancerous tissue was evaluated using receiver-operating-characteristics analysis. RESULTS: The Kep and Kel values were significantly greater in cancerous tissue (0.13 sec(-1) +/- 0.14 and 1.59 x 10(-3) sec(-1) +/- 1.35 x 10(-3)) than in non-cancerous tissue from the central gland (0.03 sec(-1) +/- 0.02 and 0.26 x 10(-3) sec(-1) +/- 1.24 x 10(-3)) and peripheral zone (0.04 sec(-1) +/- 0.07 and 0.58 x 10(-3) sec(-1) +/- 1.98 x10(-3)) (p < 0.05). The area under the ROC curve for differentiating cancerous from non-cancerous tissue was 0.850 (95% CI, 0.778-0.876) for Kep and 0.814 (95% CI, 0.737-0.876) for Kel. CONCLUSION: Kep and Kel are useful perfusion parameters for the differentiation of prostate cancerous tissue from non-cancerous tissue.
