Effects of Sub Minimal Inhibitory Concentration of Metronidazole and Penicillin on Morphology of Aggregatibacter actinomycetemcomitans: Scanning Electron Microscopy Observation.
10.11620/IJOB.2015.40.1.035
- Author:
Ye Won KWON
1
;
Si Young LEE
Author Information
1. Department of Oral Microbiology, College of Dentistry, Research Institute of Oral Science, Gangneung-Wonju National University, Gangneung, 210-702, Korea. siyoung@gwnu.ac.kr
- Publication Type:Original Article
- Keywords:
antibiotic;
Aggregatibacter actinomycetemcomitans;
morphology;
sub-MIC
- MeSH:
Aggregatibacter actinomycetemcomitans*;
Anti-Bacterial Agents;
Bacteria;
Metronidazole*;
Microscopy, Electron, Scanning*;
Penicillins*
- From:International Journal of Oral Biology
2015;40(1):35-39
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Minimal inhibitory concentration (MIC) is the lowest concentration of antibiotics that inhibits the visible growth of bacteria. It has been reported that sub-MIC of antibiotics may result in morphological alterations, along with the biochemical and physiological changes in bacteria. The purpose of this study was to examine morphological changes of Aggregatibacter actinomycetemcomitans, after the treatment with sub-MIC metronidazole and penicillin. The bacterial morphology was observed with scanning electron microscope, after incubating with sub-MIC antibiotics. The length of A. actinomycetemcomitans was increased after the incubation with sub-MIC metronidazole and penicillin. Sub-MIC metronidazole and penicillin inhibited bacterial division and induced long filaments. Our study showed that metronidazole and penicillin can induce the morphological changes in A. actinomycetemcomitans.
