Helicobacter pylori: Bacterial Strategy for Incipient Stage and Persistent Colonization in Human Gastric Niches.
10.3349/ymj.2014.55.6.1453
- Author:
Kwang Ho RHEE
1
;
Jin Sik PARK
;
Myung Je CHO
Author Information
1. Department of Microbiology, Gyeongsang National University College of Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju, Korea. mjecho@gnu.ac.kr
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords:
Helicobacter pylori;
gastric infection;
persistent colonization;
pathogenesis
- MeSH:
Gastric Mucosa/*microbiology;
Gastritis/*microbiology/pathology;
Helicobacter Infections/*microbiology;
Helicobacter pylori/*physiology;
Humans;
Stomach Neoplasms/pathology
- From:Yonsei Medical Journal
2014;55(6):1453-1466
- CountryRepublic of Korea
- Language:English
-
Abstract:
Helicobacter pylori (H. pylori) undergoes decades long colonization of the gastric mucosa of half the population in the world to produce acute and chronic gastritis at the beginning of infection, progressing to more severe disorders, including peptic ulcer disease and gastric cancer. Prolonged carriage of H. pylori is the most crucial factor for the pathogenesis of gastric maladies. Bacterial persistence in the gastric mucosa depends on bacterial factors as well as host factors. Herein, the host and bacterial components responsible for the incipient stages of H. pylori infection are reviewed and discussed. Bacterial adhesion and adaptation is presented to explain the persistence of H. pylori colonization in the gastric mucosa, in which bacterial evasion of host defense systems and genomic diversity are included.
