Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea.
10.3349/ymj.2014.55.6.1562
- Author:
Jung Hye HWANG
1
;
Jeong Wook KIM
;
Ji Young HWANG
;
Kyung Min LEE
;
Hye Min SHIM
;
Young Kyung BAE
;
Seung Sam PAIK
;
Hosun PARK
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Coxsackievirus;
missed abortion;
fetal anomaly
- MeSH:
Abortion, Missed/*etiology;
Adult;
Coxsackievirus Infections/complications/*diagnosis/virology;
Enterovirus B, Human/genetics/*isolation & purification;
Female;
Humans;
Immunohistochemistry;
Placenta/virology;
Pregnancy;
Pregnancy Complications, Infectious/*virology;
Pregnancy Trimester, First;
Prevalence;
Prospective Studies;
Republic of Korea;
Reverse Transcriptase Polymerase Chain Reaction;
Sequence Analysis, DNA;
Uterus/*virology
- From:Yonsei Medical Journal
2014;55(6):1562-1567
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. MATERIALS AND METHODS: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR. RESULTS: Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. CONCLUSION: The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
