Successful systemic thrombolysis of both the inferior vena cava and a renal vein thrombi that complicated nephrotic syndrome.
- Author:
Hyung Seok LEE
1
;
Jin Taek KIM
;
Joo Won MIN
;
Giyoung KWON
;
Bong Soo KIM
;
Guk Myung CHOI
;
Woo Heon KANG
Author Information
1. Department of Nephrology, Hanmaum Hospital, Jeju, Korea. kangdoc@hanmail.net
- Publication Type:Case Report
- Keywords:
Thrombolysis;
Thromboembolism;
Nephrotic syndrome
- MeSH:
Acute Kidney Injury;
Flank Pain;
Hemorrhage;
Humans;
Hypoalbuminemia;
Male;
Nephrotic Syndrome*;
Pulmonary Embolism;
Renal Veins*;
Risk Factors;
Thromboembolism;
Thrombosis;
Tomography, X-Ray Computed;
Urokinase-Type Plasminogen Activator;
Vena Cava, Inferior*;
Young Adult
- From:Korean Journal of Medicine
2007;73(4):448-452
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Nephrotic syndrome has been considered a hypercoagulable state because thromboembolic events of the venous or the arterial circulations occur on occasion. There are various risk factors for thromboembolism in patients with nephrotic syndrome (membranous nephropathy, severe hypoalbuminemia, hemoconcentration and medications such as steroid and diuretics). As thromboembolism is often fatal, early detection and proper management are important. Although anticoagulation is the preferred therapy, thrombolysis may be considered for an extensive thrombosis, for inferior vena cava (IVC) thrombosis, for recurrent pulmonary thromboembolism and for bilateral renal vein thrombosis in conjunction with acute renal failure. We report here on a case of renal vein and IVC thrombosis in a 24-year-old male with nephrotic syndrome, and this patient was treated with intravenous thrombolytics rather than anticoagulation and local thrombolytic infusion. He complained of left flank pain and his CT scan revealed left renal vein thrombosis and IVC thrombosis. After urokinase infusion, his thrombi were resolved successfully without bleeding complications.
