Dose - response for Glycopyrrloate and Heart Rate in Children Anesthetized with Halothane and Nitrous Oxide.
10.4097/kjae.1993.26.2.243
- Author:
Ji Young SON
1
;
Po Sun KANG
;
Young Chul PARK
;
Suk Min YOON
Author Information
1. Department of Anesthesiology, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Anesthesia;
pediatric;
Heart rate;
Anesthetics;
halothane;
nitrous oxide;
Anticholinergic drugs;
glycopyrrolate
- MeSH:
Anesthesia;
Anesthetics;
Blood Pressure;
Child*;
Glycopyrrolate;
Halothane*;
Heart Rate*;
Heart*;
Humans;
Nitrous Oxide*;
Oxygen
- From:Korean Journal of Anesthesiology
1993;26(2):243-249
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The dose-response for glycopyrrolate and heart rate in anesthetized children has not heen defined. We determined the dose-response for glyeopyrrolate and heart rate in 50 children, ASA physical status l and 2, anesthetized with halothane and nitrous oxide. Anesthesia was induced with 60-70% nitrous oxide in oxygen and halothane(1.5-2.0 vo1%). After induction of aneethesia, glycopyrrolate in a dose of 4, 6, 8, 12 or 16ug Xkg(-1) was administered by rapid infusion to each subject. The effects of glycopyrrolate on heart rate, heart rhythm and systolic blood pressure were compared among dosage groups, and dose-response curve for peak heart rate was constructed, Glycopyrrolate increased the heart rate in a dose-related manner upto 12 ug X kg(-1) except 16 ugX kg(-1). Fifty percent maximal response corresponded to 6.1 ug X kg(-1), and 95% maximal response corresponded to 11.1 ug X kg(-1) . None of the patients had nonsinus rhythm after glycopyrrolate injection. Except for glycopyrrolate given at 4 ug x kg(-1), the systolic blood pressure increased significantly after all other doses. Glycopyrrolate in doses greater than or equal to 6 ug X kg(-1) increased the heart rate and systolic blood pressure in children anesthetized with halothane and nitrous oxide.
