Blood Concentration of Lidocaine after Subarachnoid Administration.
10.4097/kjae.1993.26.2.310
- Author:
Jae Kyu CHEUN
1
;
Ae Ra KIM
;
Dae Lim JEE
;
Yeon Kyu KIM
Author Information
1. Department of Anesthesiology, Keimyung University School of Medicine, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Spinal anesthesia;
Blood lidocaine concentration
- MeSH:
Absorption;
Adult;
Anesthesia, Spinal;
Female;
Glucose;
Humans;
Hysterectomy;
Lidocaine*
- From:Korean Journal of Anesthesiology
1993;26(2):310-313
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ten healthy adult female patients scheduled for elective abdominal hysterectomy were evaluated for their rates and degrees of absorption following subarachnoid administration of 150 mg of 5% lidocaine in 5% dextrose solution. The mean blood concentrations of lidocaine measured at 5, 15, 30, 60 and 90 minutes after subarachnoid administration were 0.34+/-0.23, 0.78+/-0.27, 1.10+/-0.26, 1.24+/-0.24 and 1.07+/-0.19 mcg/ ml, respectively. The mean values of Cmax and Tmax obtained from these measurements were 1.30+/- 0.21 mcg/ml and 57+/-17 minutes, respectively. These results revealed that in comparison with other regional administration, absorption of lidocaine follwing subarachnoid injection is slower.
