Chemical Constituents from Leaves of Acanthopanax henryi (II).
- Author:
Zhi LI
1
;
Xiao Jun LI
;
Ok Kyoung KWON
;
Xiang WANG
;
Qin Peng ZOU
;
Xiang Qian LIU
;
Hyeong kyu LEE
Author Information
1. School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People's Republic of China. lxq0001cn@163.com
- Publication Type:Original Article
- Keywords:
Araliaceae;
Acanthopanax henryi;
Triterpenoid saponins;
Anthraquinone;
Nitric oxide;
Anti-inflammatory
- MeSH:
Eleutherococcus*;
Araliaceae;
Interleukin-6;
Macrophages;
Nitric Oxide;
Saponins;
Tumor Necrosis Factor-alpha
- From:Natural Product Sciences
2015;21(3):196-204
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nineteen compounds, including one organic acid (1), one anthraquinone (2), one amide (3), and sixteen triterpenoid saponins (4 - 19) were isolated from the leaves of Acanthopanax henryi (Oliv.) Harms (Araliaceae). Their structures were determined on the basis of physicochemical properties and spectral analyses (HR-MS and NMR). Among them, compounds 2, 3, 7, 12 and 19 were new within Araliaceae. Compounds 4, 5, 9 - 11, 13, 14, 16 and 18 were reported for the first time from the Acanthopanax genus. Except for compounds 4 and 9, other compounds were isolated from A. henryi (Oliv.) Harms for the first time. The rare anthraquinone, compound 2, significantly decreased the production of NO and the levels of other inflammatory factors, such as TNF-alpha and IL-6, in lipopolysaccharide (LPS)-stimulated macrophages in a dose-dependent manner. This is the first time to report anti-inflammatory effect of this compound.
