Anti-inflammatory Activity of Fucoidan with Blocking NF-kappaB and STAT1 in Human Keratinocytes Cells.
- Author:
Min Ju RYU
1
;
Ha Sook CHUNG
Author Information
1. College of Natural Sciences, Duksung Women's University, Seoul 132-714, Korea. hasook@duksung.ac.kr
- Publication Type:Original Article
- Keywords:
Fucoidan;
Anti-inflammation;
Chemokine;
Nuclear factor-kappa B;
Signal transducer and activator of transcription 1
- MeSH:
Chemokine CCL17;
Chemokines;
Dermatitis, Atopic;
Humans*;
Keratinocytes*;
NF-kappa B*;
Phaeophyta;
Phosphorylation;
Phosphotransferases;
RNA, Messenger;
Skin Diseases;
STAT1 Transcription Factor;
Transducers
- From:Natural Product Sciences
2015;21(3):205-209
- CountryRepublic of Korea
- Language:English
-
Abstract:
Fucoidan, a sulfated polysaccharide is found in several types of edible brown algae. It has shown numerous biological activities; however, the molecular mechanisms on the activity against atopic dermatitis have not been reported yet. We now examined the effects of fucoidan on chemokine production co-induced by TNF-alpha/IFN-gamma, and the possible mechanisms underlying these biological effects. Our data showed that fucoidan inhibited the TNF-alpha/IFN-gamma-induced production of thymus and activation-regulated chemokine (TARC) and macrophagederived chemokine (MDC) mRNA in human keratinocytes HaCaT cells. Also, fucoidan suppressed phosphorylation of nuclear factor kappa B (NF-kappaB) and activation of signal transducer and activator of transcription (STAT)1 in a dose-dependent manner. In addition, fucoidan significantly inhibited activation of extracellular-signal-regulated kinases (ERK) phosphorylation. These data indicate that fucoidan shows anti-inflammatory effects by suppressing the expression of TNF-alpha/IFN-gamma-induced chemokines by blocking NF-kappaB, STAT1, and ERK1/2 activation, suggestive of as used as a therapeutic application in inflammatory skin diseases, such as atopic dermatitis.
