Molecular Biology of Upper Gastrointestinal Neoplasms.
10.7704/kjhugr.2012.12.2.75
- Author:
Joon Sung KIM
1
;
Byung Wook KIM
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Incheon, Korea. gastro@catholic.ac.kr
- Publication Type:Review
- Keywords:
Neoplasms;
Upper gastrointestinal tract;
Molecular biology
- MeSH:
Adenocarcinoma;
Carcinoma, Squamous Cell;
Chemoprevention;
Esophageal Neoplasms;
Gastrointestinal Neoplasms;
Humans;
Molecular Biology;
Prognosis;
Upper Gastrointestinal Tract
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research
2012;12(2):75-81
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neoplasms of the upper gastrointestinal tract are related by location and have distinct clinical and molecular characteristics. Malignancies of the upper gastrointestinal tract are often diagnosed at an advanced stage and are generally associated with a poor patient prognosis. Improved understanding of the molecular biology of these tumors should provide new targets for diagnosis, chemoprevention, and therapy. This review focuses on the molecular biology of esophageal adenocarcinoma, esophageal squamous cell carcinoma and gastric adenocarcinoma. Fundamental principles of carcinogenesis are discussed first, followed by the key similarities and differences of each cancer.
