Fasting, Blood Glucose Level and its RIsk of Pancreatic Cancer among Koreans: A Prospective Study.
- Author:
Hee Jin KIM
1
;
Sun Ha JEE
;
Hong Soo LEE
;
Sang Hwa LEE
;
Kyung Won SHIM
Author Information
1. Department of Family Medicine, Eulji University School of Medicine, Eulji Hospital, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
fasting blood glucose;
diabetes mellitus;
pancreatic neoplasms;
prospective studies
- MeSH:
Blood Glucose*;
Cohort Studies;
Diabetes Mellitus;
Fasting*;
Female;
Humans;
Life Style;
Male;
Mortality;
Pancreatic Neoplasms*;
Proportional Hazards Models;
Prospective Studies*;
Smoke;
Smoking;
Surveys and Questionnaires
- From:Journal of the Korean Academy of Family Medicine
2006;27(4):261-269
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Previous studies reported an increased risk of pancreatic cancer among diabetes patients, and fasting blood glucose level is widely used to determine the presence of diabetes mellitus. The aim of this study was to analyze the influence of fasting blood glucose level on pancreatic cancer death by a large, prospective cohort study in Korean population. METHODS: A total of 1,306,476 participants in the Korean Cancer Prevention Study (KCPS) were enrolled. A health examination including fasting blood glucose level and life style questionnaire was done as a baseline examination from 1993 to 1995, and they were followed up to 2002. Pancreatic cancer death outcome for 10 years according to the fasting blood glucose level was explored. RESULTS: At the beginning 63,510 (4.9%) participants had diabetes mellitus. In multivariate Cox proportional hazards models, controlling for age and current smoking, the presence of diabetes increased the risk of mortality for pancreatic cancer excluding those who died of pancreatic cancer within 1 year (Men: HR 1.7; 95% CI, 1.4~2.1, P<0.0001, Women: HR 1.8; 95% CI, 1.3~2.6, P=0.0003). As fasting blood glucose level, elivated the pancreatic cancer risk was increased. Men with fasting blood glucose level > or =140 mg/dL had a higher risk of pancreatic cancer than those with FBG <100 mg/dl. (Men: HR 2.0; 95% CI, 1.6~2.5, P<0.0001, Women: HR 2.1; 95% CI, 1.4~3.1, P=0.0002). CONCLUSION: Elevated fasting blood glucose level increased the risk of pancreatic cancer death among Koreans.
