Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload.
10.3346/jkms.2013.28.11.1563
- Author:
Jun Ho JANG
1
;
Je Hwan LEE
;
Sung Soo YOON
;
Deog Yeon JO
;
Hyeoung Joon KIM
;
Jooseop CHUNG
;
Jong Wook LEE
Author Information
1. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Review ; Guideline
- Keywords:
Korean Guideline;
Iron Overload;
Deferasirox
- MeSH:
Anemia, Aplastic/therapy;
Benzoates/therapeutic use;
Blood Transfusion/*adverse effects;
Chelation Therapy/*methods;
Humans;
Iron Chelating Agents/*therapeutic use;
Iron Overload/*therapy;
Myelodysplastic Syndromes/therapy;
Pyridones/therapeutic use;
Republic of Korea;
Triazoles/therapeutic use
- From:Journal of Korean Medical Science
2013;28(11):1563-1572
- CountryRepublic of Korea
- Language:English
-
Abstract:
Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an appropriate chelator, most patients have not been treated effectively. Deferasirox (DFX), a once-daily oral iron chelator for both adult and pediatric patients with transfusion-induced iron overload, is now available in Korea. The effectiveness of deferasirox in reducing or maintaining body iron has been demonstrated in many studies of patients with a variety of transfusion-induced anemias such as myelodysplastic syndromes, aplastic anemia, and other chronic anemias. The recommended initial daily dose of DFX is 20 mg/kg body weight, taken on an empty stomach at least 30 min before food and serum ferritin levels should be maintained below 1000 ng/mL. To optimize the management of transfusion-induced iron overload, the Korean Society of Hematology Aplastic Anemia Working Party (KSHAAWP) reviewed the general consensus on iron overload and the Korean data on the clinical benefits of iron chelation therapy, and developed a Korean guideline for the treatment of iron overload.
