The Effects of Alfentanil and a Combination of Alfentanil and Esmolol on Hemodynamic Responses after Endotracheal Intubation in Hypertensive Patients.
10.4097/kjae.2005.49.2.136
- Author:
Hyun KANG
1
;
In Goo LEE
;
Choon Kyu CHO
;
Chong Hwa BAEK
;
Jung Won PARK
;
Yong Hun JUNG
;
Young Cheol WOO
;
Jin Yun KIM
;
Gill Hoi KOO
;
Sun Gyoo PARK
Author Information
1. Department of Anesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. jyk5399@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
alfentanil;
esmolol;
hypertension;
intubation
- MeSH:
Alfentanil*;
Anesthesia;
Blood Pressure;
Bradycardia;
Heart Rate;
Hemodynamics*;
Humans;
Hypertension;
Hypotension;
Intubation;
Intubation, Intratracheal*;
Succinylcholine;
Tachycardia;
Thiopental;
Vecuronium Bromide
- From:Korean Journal of Anesthesiology
2005;49(2):136-141
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was desined to determine the efficacy and clincial usefulness of alfentanil and a combined use of alfentanil and esmolol for blunting hemodynamic responses after tracheal intubation in hypertensive patients who needed a rapid sequence induction. METHODS: Group 1 received alfentanil 15microgram/kg and group 2 received alfentanil 15microgram/kg and esmolol 1 mg/kg intravenously. Thiopental sodium 5 mg/kg and succinylcholine 1 mg/kg were used for the induction of anesthesia. Changes in blood pressure and herat rate were measured during intubation and induction of anesthesia with enflurane-N2O-O2 and vecuronium. Rate pressure products (RPP) was calculated and the frequencies of hypertension, hypotension, tachycardia, bradycardia were measured. RESULTS: In group 1, systolic blood pressure increased significantly at 1, 2 minute and decreased significantly at 4, 5, 10, 15 minute compared to base, and diastolic blood pressure increased significantly at 1 minute and decreased significantly at 4, 5, 10 minute. Heart rate increased significantly at 1, 2 minute. In group 2, systolic blood pressure decrease significantly at 3, 4, 5 minute after tracheal intubation compared to base, and diastolic blood pressure increased at 1 minute and decreased at 4, 5, 10, 15 minute. HR did not change significantly (P < 0.05). CONCLUSION: In treated hypertensive patients, the use of a combination of alfentanil 15/kg and esmolol 1 mg/kg is a useful method to attenuate hemodynamic responses after endotracheal intubation and especially for rapid sequence induction.
