The Prognosis of Ocular-adnexal Lymphoproliferative Lesions.
- Author:
Yun Sun LEE
1
;
Moo Ill LEE
;
Tae Sung PARK
;
Sang Yeul LEE
Author Information
1. Department of Ophthalmology, Inha University College of Medicine, Korea. yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Extraorbital spread;
Mucosa-associated lymphoid tissue (MALT-lymphoma);
Recurrence
- MeSH:
Biopsy;
Classification;
Conjunctiva;
Eyelids;
Follow-Up Studies;
Humans;
Hyperplasia;
Korea;
Lymphoid Tissue;
Lymphoma;
Lymphoma, B-Cell;
Lymphoma, B-Cell, Marginal Zone;
Orbit;
Prognosis*;
Radiotherapy;
Recurrence;
Retrospective Studies
- From:Journal of the Korean Ophthalmological Society
2003;44(6):1260-1267
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Lymphoproliferative lesions of the ocular adnexa were analyzed to examine the final outcome, recurrence and extraorbital spread. METHODS: The biopsies and clinical follow up data for 55 patients (68 eyes) with ocular adnexal lymphoproliferative lesions were reviewed retrospectively and analyzed according to the WHO classification. RESULTS: The ocular-adnexal lymphoproliferative lesions were located as follows: orbit in 49 eyes, conjunctiva in 18 eyes, eyelid in 1 eye. The three main subtypes of lymphoma according to the WHO classification were extranodal marginal zone B-cell lymphoma of mucosa- associated lymphoid tissue (MALT-lymphoma) (62 eyes), diffuse large B-cell lymphoma (2 eyes), and benign lymphoid hyperplasia (4 eyes). Remission was achieved at 60eyes. Recurrence was occurred in 7eyes (orbit: 4, conjunctiva: 3) of MALT-lymphoma cases. Location of lymphoma at presentation was not a predictor for recurrence (conjunctiva 16.7%, orbit 8.2%; p>0.05), but bilaterality at presentation was predictive values for recurrence by a statistically significant difference(bilateral 23.1%, unilateral 4.8%; p=0.045). CONCLUSIONS: Most common ocular adnexal lymphoma in Korea was MALT- lymphoma (91.2%). Bilaterality has a predictive values on recurrence, and extraorbital spread was found only in orbital MALT-lymphoma. It is suggested that orbital MALT- lymphoma should be treated with excisional biopsy and subsequent low dose radiotherapy and followed up indefinity.
