Alteration of Ventricular Repolarization by Intracoronary Infusion of Normal Saline in Patients With Variant Angina.
10.4070/kcj.2009.39.6.223
- Author:
Jae Kwon KIM
1
;
Nam Ho KIM
;
Ik Sang SHIN
;
Dong Hyo NOH
;
Yong Cheol KIM
;
Seung Hwan KIM
;
Jun Ho CHOI
;
Eun Mi PARK
;
Sang Jae LEE
;
Kyeong Ho YUN
;
Nam Jin YOO
;
Eun Mi LEE
;
Seok Kyu OH
;
Jin Won JEONG
Author Information
1. Cardiovascular Center, Wonkwang University Hospital, Iksan, Korea. cardionh@wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Angiography;
Sodium chloride;
Angina pectoris, variant;
Arrhytromia, cardiac
- MeSH:
Angina Pectoris, Variant;
Angiography;
Blood Pressure;
Catheters;
Coronary Angiography;
Coronary Vessels;
Glucose;
Heart Rate;
Humans;
Ions;
Sodium;
Sodium Chloride
- From:Korean Circulation Journal
2009;39(6):223-227
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: During coronary angiography and interventional procedures, catheters that are engaged in a coronary ostium are routinely flushed, typically with normal saline, to expel blood from the catheter or to inject a pharmacologic agent. Saline contains sodium and chloride ions. Such injections may affect the electrophysiologic properties of the myocardium; however, the effect of normal saline on ventricular repolarization has not been established in patients with variant angina. SUBJECTS AND METHODS: We studied 51 consecutive patients with variant angina. Five mL of normal saline (NS) or 5% dextrose solution (DW) were infused into the left coronary artery in random order. We measured the heart rate, QT interval, and T-wave amplitude using Mac-Lac 5.2. RESULTS: The baseline clinical characteristics were not different between the NS {n=30 (14 males); mean age, 56+/-10 years} and the 5% DW groups {n=21 (7 males); mean age, 59+/-10 years}. The changes in the mean corrected QT (QTc) interval were significantly increased at the time of infusion of NS compared to 5% DW (45.1+/-30.3 vs. 20.9+/-23.3 ms, p=0.004). There was a T-wave amplitude change >0.2 mV in at least one-lead in 27 patients (90.0%) during NS infusion compared to 7 patients (33.3%) during 5% DW infusions (p=0.001). No significant changes in heart rate and blood pressure were noted during of the infusions. CONCLUSION: NS was associated with prolongation of ventricular repolarization in patients with variant angina.
