NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats.
10.4142/jvs.2009.10.2.141
- Author:
Sung Hoon PARK
1
;
Noton Kumar DUTTA
;
Min Won BAEK
;
Dong Jae KIM
;
Yi Rang NA
;
Seung Hyeok SEOK
;
Byoung Hee LEE
;
Ji Eun CHO
;
Geon Sik CHO
;
Jae Hak PARK
Author Information
1. Laboratory Animal Medicine, and KRF Priority Zoonotic Disease Research Institute, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. pjhak@snu.ac.kr
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
chitosan;
hypertension;
KCl;
NaCl;
spontaneously hypertensive rat
- MeSH:
Angiotensin I/blood;
Angiotensin II/biosynthesis;
Animals;
Blood Pressure/*drug effects/physiology;
Blood Urea Nitrogen;
Body Weight/drug effects;
Chitosan/*administration & dosage;
Chlorides/blood/urine;
Creatinine/urine;
Heart/physiology;
Histocytochemistry;
Hypertension/*prevention & control;
Kidney/physiology;
Male;
Potassium/blood/urine;
Potassium Chloride/administration & dosage;
Random Allocation;
Rats;
Rats, Inbred SHR;
Sodium/blood/urine;
Sodium Chloride, Dietary/*administration & dosage;
Systole/drug effects/physiology
- From:Journal of Veterinary Science
2009;10(2):141-146
- CountryRepublic of Korea
- Language:English
-
Abstract:
The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na+ excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.
