Inflammatory Skin Response to Ultraviolet Radiation: Ear Swelling Response in C57BL Mouse.
- Author:
Un Cheol YEO
;
Ki Ho KIM
;
Mi Kyung JO
;
Hwan Pyo JEON
;
Joo Heung REE
;
Ai Young LEE
;
Jai Il YOUN
- Publication Type:Original Article
- Keywords:
Ear swelling response;
UVB;
C57BL mouse
- MeSH:
Animals;
Ear*;
Mice;
Mice, Inbred C57BL*;
Skin*
- From:Korean Journal of Dermatology
1989;27(6):650-654
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was undertaken to investigate the change of ear swelling response (ESR) of the mice according to repetitive ultraviolet radiation. 100mJ/crn of UVB was irradiated daily for 4 weeks, and a total of 25 C57BL mice were used as subjects. The results were as follows : 1. After 1 day, 2 days and 3 days irradiation of UVB, ESR reached 21.3+/-1.5, 22.3+/-1.1 and 24.3+/-1.6 respectively with increasing tendency, but there was no statistical significance (Wilcoxon rank sum test p>0.05). 2. ESR reached at maximum, 78.0+/-1.8, after 1 week(p<0.01), thereafter ESR decreased gradually with reparative process. 3. Inspite of continued irradiation, ESR decreased gradually after 2 weeks. After 2 weeks, 3 weeks and 4 weeks irradiation, ESR decreased to 51.6+/-11.8, 45.1+/- 3.3 and 42.8+/-6.8 respectively, but, there were still increment of ESR (p<0.01).
