Detection of Human Papillomavirus DNA in Condylomata Acuminata Patients using Molecular Hybridization.
- Author:
Kyoung Chan PARK
;
Sang Hak LEE
;
Yoo Shin LEE
;
Young Kee KIM
;
Heung Bae PARK
;
Jeong Seon SEO
- Publication Type:Original Article
- Keywords:
Genital warts;
HPV;
Southern blot hybridization
- MeSH:
Blotting, Southern;
Condylomata Acuminata*;
DNA*;
Humans*;
Korea
- From:Korean Journal of Dermatology
1989;27(6):660-665
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Condylomata acuminata are benign tumors which are mostly venereally transmitted. Common sites were coronal sulcus, perisnal area and prepuce. Among 28 patients, 21 acuminate lesions and 10 papular lesions were found. Twenty eight human genital warts in Korean were analysed by Southern blot hybridization. Sequences related to HPV6/11 are found in 89.3%(25/28) of the condylomata. HPV16 DNA was not found at sll. Subtype of HPV was determined by the restriction pattern of DNA cleaved with PstI restriction enzyme in 7 cases. Six cases of HPV6a and one case of HPV6c are found. The above results suggest that most of condylomata acuminata are caused by HPV6 and HPV11 in Korea.
