The Onset of Coronary Artery Aneurysm and Changes of T Cell Subsets and the Effect of High Dose Gammaglobulin Therapy in Mucocutanenous Lymph Node Syndrome.
10.4070/kcj.1992.22.2.269
- Author:
Seung Hwan KIM
;
Mi Ryoung KIM
;
Young Gyun OH
;
Byung Kiu PARK
;
Moon Hong DOH
;
Bong Kwan SEO
;
Myung Kul YUM
- Publication Type:Original Article
- Keywords:
MCLS;
Coronary aneurysm;
T cell Subsets
- MeSH:
Aneurysm*;
Coronary Aneurysm;
Coronary Vessels*;
gamma-Globulins;
Humans;
Immunoglobulins;
Lymph Nodes*;
Lymphocytes;
Mucocutaneous Lymph Node Syndrome;
T-Lymphocyte Subsets*
- From:Korean Circulation Journal
1992;22(2):269-279
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We studied the onset of coronary artery aneurysm formation in 42 patients of Mucocutaneous lymph node syndrome (MCLS), the serial changes of T cell subsets, and serum immunoglobulin levels including lgG, lgA, lgM, in 13 patients among them during acute (before high dose gamma-globulin therapy ) and subacute phase (after gamma-globulin therapy) to evaluate the role of the immunoregulatory abnormalities in coronary artery aneurysm formation. The following results are obtainded : 1) The coronary artery aneurysm was found in 16 patients (38%). They were detected in between 6th and 13th day of illness with the mean of 8.8+/-2.1 day. 2) The total T lymphocyte (T1), helper T lymphocyte (T4), and helper/supperessor ratio (T4/T8) decreased during acute phase. 3) Following gamma-globulin therapy it showed a increase in T4,T8, and all immunoglobulines. Above results showed that the most of aneurysms developed during acute phase and suppressed, rather than enhanced, T cell function significantly contributed to aneurysm formation, whereas high dose gamma-globulin retarded or reversed this suppression which would be one of mechanism of beneficial effort of gamma-globulin in MCLS.
