A Case of Prenatal Diagnosis of Congenital Fetal Goiter in Hyperthyroidism Mother.
- Author:
Dong Han BAE
;
Young Hwa KIM
;
Kyu Yeon CHOI
;
K T JANG
;
Sang Yeob KIM
- Publication Type:Case Report
- Keywords:
Graves' disease;
Fetal goiter;
Congenital hypothyroidism
- MeSH:
Antibodies;
Congenital Hypothyroidism;
Cordocentesis;
Female;
Fetal Blood;
Fetus;
Goiter*;
Graves Disease;
Humans;
Hyperthyroidism*;
Hypothyroidism;
Intellectual Disability;
Language Development;
Mothers*;
Parturition;
Pregnancy;
Pregnant Women;
Prenatal Diagnosis*;
Thyroid Function Tests;
Thyroid Gland;
Ultrasonography
- From:Korean Journal of Perinatology
1998;9(1):35-42
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of prenatal diagnosis of fetal congenital goiter at 31weeks of gestation by ultrasonogram and fetal hypothyroidism confirmed at birth as thyroid function test by umbilical cord blood sampling. Maternal Graves' disease and the drugs used to treat hyperthyroidism in pregnant women can affect the fetus, causing hyperthyroidism or hypothyroidism and goiter. Fetal hypothyroidism may be caused by transplacental passage of either maternal thyrotropic-binding inhibitory immunoglobulin(TBII) antibodies or maternal treatment with propylthiouracil(PTU). Untreated fetal hypothyroidism may result in mental retardation, perceptual-motor, visual-spatial, and language developmental problems. In this article fetal thyroid function was not assessed by cordocentesis, but fetal congenital goiter was detected ultrasound. Ultrasound should be used to detect fetal goiter from 20 weeks onward. Fetal goiter should resolve when maternal PTU treatment is decreased. We have diagnosed fetal hypothyroidism in utero by ultrasonography. Significance of in utero management of fetal hypothyroidism is discussed.
