Clinical Dementia Rating Orientation Score as an Excellent Predictor of the Progression to Alzheimer's Disease in Mild Cognitive Impairment.
- Author:
Jee Wook KIM
1
;
Min Soo BYUN
;
Bo Kyung SOHN
;
Dahyun YI
;
Eun Hyun SEO
;
Young Min CHOE
;
Shin Gyeom KIM
;
Hyo Jung CHOI
;
Jun Ho LEE
;
Ik Seung CHEE
;
Jong Inn WOO
;
Dong Young LEE
Author Information
- Publication Type:Original Article
- Keywords: Mild cognitive impairment; Alzheimer's disease; Clinical Dementia Rating,; Orientation; Prediction
- MeSH: Aged; Alzheimer Disease*; Dementia*; Follow-Up Studies; Humans; Logistic Models; Memory Disorders; Mild Cognitive Impairment*; Neuropsychological Tests
- From:Psychiatry Investigation 2017;14(4):420-426
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: This study aimed to examine the usefulness of each subscale score of the Clinical Dementia Rating (CDR) for predicting Alzheimer's disease (AD) dementia progression in amnestic mild cognitive impairment (MCI) elderly subjects. METHODS: Fifty-nine elderly MCI individuals were recruited from a university dementia and memory disorder clinic. Standardized clinical and neuropsychological tests were performed both at baseline and at the time of 2 years follow-up. Logistic regression analyses were conducted to examine the ability of various clinical measures or their combinations to predict progression to AD dementia in MCI individuals. RESULTS: MCIp individuals showed significantly higher CDR Orientation subscale and CDR sum-of-boxes (SOB) score than MCInp ones, while there were no significant differences in other CDR subscale scores between the two. MCIp individuals also showed marginally higher MMSE scores than MCInp ones. A series of logistic regression analyses demonstrated that the model including CDR Orientation subscale had better AD dementia prediction accuracy than either the model with either MMSE or CDR-SOB. CONCLUSION: Our findings suggest that CDR Orientation subscale score, a simple and easily available clinical measure, could provide very useful information to predict AD dementia progression in amnestic MCI individuals in real clinical settings.
