Treatment outcome of nasal natural killer/T-cell lymphoma.
10.3857/roj.2011.29.3.174
- Author:
Hyun Jin LEE
1
;
Sang Wook LEE
;
Cheolwon SUH
;
Jooryung HUH
;
Sang Min YOON
;
Young Seok KIM
;
Su San KIM
;
Jong Hoon KIM
;
Eun Kyung CHOI
;
Seung Do AHN
Author Information
1. Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. lsw@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Nasal natural killer/T-cell lymphoma;
Radiotherapy;
Concurrent chemoradiotherapy
- MeSH:
Chemoradiotherapy;
Disease-Free Survival;
Follow-Up Studies;
Humans;
Lymph Nodes;
Lymphoma;
Neoplasm Metastasis;
Recurrence;
Survival Rate;
Treatment Outcome
- From:Radiation Oncology Journal
2011;29(3):174-180
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the radiotherapy treatment outcome of patients in stage IE and IIE nasal natural killer/T-cell lymphoma. MATERIALS AND METHODS: From August 1999 to August 2009, 46 patients with stage IE and IIE nasal natural killer/T-cell lymphoma were treated by definitive radiotherapy and chemotherapy. 33 patients were treated with chemotherapy followed by radiotherapy (CT + RT) and they received 50.4 Gy in 28 fractions. 13 patients were treated with concurrent chemoradiotherapy (CCRT) and they received 40 Gy in 20 fractions. RESULTS: The median follow-up period was 4.6-137.6 months (median, 50.2 months) for all patients. The 4-year overall survival was 68.6% and 4-year disease free survival (DFS) was 61.9%. The 4-year locoregional recurrence free survival was 65.0%, and 4-year distant metastasis free survival (DMFS) was 66.2%. For patients treated with CT + RT, 15 patients (45.5%) achieved complete response after chemotherapy, and 13 patients (39.4%) achieved partial response. 13 patients (81.8%) achieved complete response after radiotherapy, and 6 patients (18.2%) achieved partial response. For patients treated with CCRT, 11 patients (84.6%) achieved complete response, and one patient (7.7%) achieved partial response. In univariate analysis, presence of cervical lymph node metastasis was only significant prognostic factor for DFS and DMFS. CONCLUSION: This study did not show satisfactory overall survival rate and disease free survival rate of definitive radiotherapy and chemotherapy for stage IE and IIE nasal natural killer/T-cell lymphoma. For patients with cervical lymph node metastasis, further investigation of new chemotherapy regimens is necessary to reduce the distant metastasis.
