Comparison of the Cobalt Alloy and Stainless Steel Core(r) Stent in a Porcine Coronary Restenosis Model.
10.4070/kcj.2005.35.7.507
- Author:
Jang Young KIM
1
;
Junghan YOON
;
Il Hyeung JUNG
;
Hee Sung WANG
;
Min Soo AHN
;
Kyung Hoon LEE
;
Byung Soo YOO
;
Seung Hwan LEE
;
Kyung Hoon CHOE
;
Yangsoo JANG
;
Jea Mo AHN
;
Yong Sun RYU
Author Information
1. Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. yoonj@wonju.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Coblat alloys;
Coronary restenosis;
Stents;
Animal model
- MeSH:
Alloys*;
Cobalt*;
Coronary Angiography;
Coronary Restenosis*;
Coronary Vessels;
Models, Animal;
Phenobarbital;
Stainless Steel*;
Stents*;
Swine
- From:Korean Circulation Journal
2005;35(7):507-512
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The stent material and thickness may influence the rate of restenosis following coronary artery stenting. A thin strut cobalt-alloy stent has been developed in an attempt to reduce the restenosis rate, while maintaining the radiopacity and radial strength. The purpose of this study was to compare a stainless steel Core(r) stent (thickness: 90 micrometer/HUMED Co. Ltd, Korea) with that of a cobalt alloy Core(r) stent (thickness: 60 micrometer/HUMED Co. Ltd, Korea) in a porcine coronary stent restenosis model. MATERIALS AND METHODS: The cobalt alloy (Co-alloy) and stainless steel (SS) stents were implanted in 24 porcine coronary arteries. Four weeks after stenting, the pigs were sacrificed after quantitative coronary angiography (QCA). The coronary arteries were perfusion-fixed and stained, and a pathological examination performed by computer-aided histomorphometry. RESULTS: The minimal luminal diameter at 4 weeks was larger in the Co-alloy than the SS group according to the QCA (1.8+/-0.8 mm vs. 2.7+/-0.8 mm, p=0.019). The neointimal area was significantly smaller in the Co-alloy than the SS group (1.96+/-0.68 mm2 vs. 0.89+/-0.27 mm2, p<0.001). The intima/media area ratio was significant lower in the Co-alloy than the SS group (1.33+/-0.46 vs. 0.69+/-0.21, p=0.003). CONCLUSION: The thin strut cobalt alloy Core(r) stent significantly reduces the neointimal formation compared to the stainless steel Core(r) stent in a porcine coronary stent injury model.
