Urinary Angiotensinogen Excretion and Intrarenal Angiotensinogen Expression in Minimal Change Disease Patients.
- Author:
Hye Ryoun JANG
1
;
Ajin JO
;
Ji Hyeon PARK
;
Jung Eun LEE
;
Wooseong HUH
;
Dae Joong KIM
;
Ha Young OH
;
Yoon Goo KIM
Author Information
1. Nephrology Division, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ygkim26@skku.edu
- Publication Type:Original Article
- Keywords:
Angiotensinogen;
Intra-renal RAS;
Minimal change disease;
Proteinuria
- MeSH:
Angiotensinogen;
Basement Membrane;
Corneal Dystrophies, Hereditary;
Enzyme-Linked Immunosorbent Assay;
Glomerulonephritis;
Humans;
Immunohistochemistry;
Nephrosis, Lipoid;
Plasma;
Proteinuria;
Renin-Angiotensin System
- From:Korean Journal of Nephrology
2011;30(6):593-600
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Urinary angiotensinogen (AGT) has been reported as an important marker reflecting the activity of intrarenal renin-angiotensin system (RAS) in chronic glomerulonephritis patients. We investigated urinary AGT excretion and intrarenal AGT expression in patients with minimal change disease (MCD). METHODS: In 20 patients with biopsy-proven MCD, urinary and plasma AGT was measured using a sandwich ELISA and intrarenal AGT expression was measured with immunohistochemistry. Urine samples from normal healthy volunteers and patients with biopsy-proven thin basement membrane disease (TBM) were used as control groups. RESULTS: MCD patients showed a wide range of natural logarithm of the urinary AGT/creatinine [ln (urinary AGT/Cr)] and the ln (urinary AGT/Cr) was higher in MCD patients compared with normal controls and TBM controls (normal control vs. TBM vs. MCD, 1.2+/-0.25 vs. 0.9+/-0.34 vs. 3.2+/-0.40). Intrarenal AGT expression was diverse in MCD patients (intrarenal AGT, arbitrary unit, 27.39-78.52 in TBM, 0.00-145.80 in MCD). Ln (urinary AGT/Cr) did not show a direct correlation with intrarenal AGT expression, plasma AGT, or urinary protein/creatinine ratio. CONCLUSION: Urinary AGT excretion and intrarenal AGT expression are enhanced in some MCD patients, suggesting that intrarenal RAS is activated in these patients.
