Significance of Peritoneal Protein Clearance in Peritoneal Dialysis Patients.
- Author:
Sul Hee YI
1
;
Ho Young LEE
;
Jung hyun KIM
;
Jae Myun JUNG
;
Soon Hyo KWON
;
Jin Seok JEON
;
Dong Cheol HAN
;
Hyunjin NOH
Author Information
1. Department of Internal Medicine, Soon Chun Hyang University, Korea. nohneph@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
Peritoneal fluid;
Protein;
Peritoneal dialysis;
Treatment outcome
- MeSH:
Ascitic Fluid;
Cardiovascular Diseases;
Comorbidity;
Creatinine;
Demography;
Diabetes Mellitus;
Dialysis;
Follow-Up Studies;
Humans;
Male;
Multivariate Analysis;
Peritoneal Dialysis;
Peritoneal Dialysis, Continuous Ambulatory;
Retrospective Studies;
Serum Albumin;
Treatment Outcome
- From:Korean Journal of Nephrology
2011;30(6):638-646
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: It has been reported recently that peritoneal protein clearance (Pcl) is a marker of endothelial dysfunction and cardiovascular disease in peritoneal dialysis patients. We evaluated whether baseline or longitudinal follow-up Pcl is a factor to consider in predicting the outcome in peritoneal dialysis patients for the follow-up period. METHODS: Patients who initiated continuous ambulatory peritoneal dialysis at our center from September 1994 to January 2006 and had a baseline peritoneal equilibration test, measurement of dialysis adequacy, and 24-h dialysate Pcl (24hr dialysate protein loss/ [serum albumin/0.4783]) were included. Demography, comorbidities, and biochemical data were retrospectively collected. Follow-up was until death or the end of the period studied (November 2009). RESULTS: A total of 203 patients (56% men, mean age 55.0+/-12.5; 55.2% with diabetes; 22.2% with cardiovascular disease) were included. The mean follow up period was 38 months (3-170 months). Baseline Pcl was 128.2 ml/day. Follow up data of Pcl were not changed from baseline period. Cox's analysis revealed the predictors of mortality (and technical failure) were age and diabetes mellitus but not dialysate/plasma creatinine ratio (D/Pcr) and Pcl. On multivariate analysis, Pcl was negatively correlated with serum albumin and triglyceride and positively correlated with D/Pcr and peritoneal creatinine clearance. CONCLUSION: Our study showed that the changes in Pcl over time were not significant from baseline up to 53 months. Neither baseline nor mean Pcl during the follow-up period were independent predictors for technical or patient survival.
