Amiodarone Induced Blue-gray Pigmentation.
- Author:
Eun Ah CHO
1
;
Hoon KANG
;
Seung Dong LEE
Author Information
1. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. lsderma@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Amiodarone;
Blue-gray pigmentation;
Hyperpigmentation
- MeSH:
Amiodarone;
Arrhythmias, Cardiac;
Benzofurans;
Biopsy;
Europe;
Follow-Up Studies;
Humans;
Hyperpigmentation;
Middle Aged;
Pigmentation;
Skin
- From:Korean Journal of Dermatology
2009;47(3):375-377
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Amiodarone (AD) is a benzofuran derivative that has been used for the treatment of recurrent arrhythmia and as a coronary vasodilator in Europe since 1964. AD-related hyperpigmentation develops after an average of 20 months of continuous AD treatment and with a minimal total dose of 160 g AD in less than 10% of the patients. A 49-year-old man presented with asymptomatic blue-gray patches that had slowly developed on the face over the previous 3 months. He had been taken amiodarone continuously for 39 months (cumulative dose: 974 g). A skin lesion biopsy from the face showed many dermal melanophages containing brown granules. The AD was discontinued and he begin using sunscreen and is courrently being followed-up. The skin discoloration was still evident, but slightly diminished at five month's follow up.
