Mechanisms of Acquiring Carbapenem-resistance in Acinetobacter Species.
- Author:
Seok Hoon JEONG
1
Author Information
- Publication Type:Review
- Keywords: Acinetobacter; OXA carbapenemase; OXA- 51; OXA-23; Metallo-beta-lactamase; Outer membrane protein; AdeABC efflux pump
- MeSH: Acinetobacter; Korea; Membrane Proteins; Oxytocin; Penicillin-Binding Proteins
- From:Korean Journal of Clinical Microbiology 2009;12(1):1-5
- CountryRepublic of Korea
- Language:Korean
- Abstract: A rapid dissemination of carbapenem-resistant Acinetobacter spp. represents a significant clinical threat. Production of OXA carbapenemases and metallo-beta- lactamases (MBLs) is the most important mechanism in acquiring carbapenem resistance in Acinetobacter spp. Carbapenem resistance has also ascribed to non- enzymatic mechanisms, including changes in outer membrane proteins, alterations in the affinity or expression of penicillin-binding proteins, and overexpression of efflux pumps. The most important mechanism in A. baumannii isolates from Korea is the production of OXA-23, while that in other species of Acinetobacter is the production of metallo-beta-lactamases.
