The Efficacy of Topical Photodynamic Therapy with a Light-Emitting Diode (LED) Device for Recalcitrant Hand and Foot Warts .
- Author:
Tae Yoon KIM
1
;
Dong Hyun KIM
;
Moon Soo YOON
Author Information
1. Department of Dermatology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Korea. msyoon@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Photodynamic;
Recalcitrant;
Wart
- MeSH:
Enzyme Multiplied Immunoassay Technique;
Foot;
Hand;
Humans;
Hyperpigmentation;
Light;
Photochemotherapy;
Triazenes;
Warts
- From:Korean Journal of Dermatology
2009;47(10):1141-1148
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The treatment of recalcitrant hand and foot warts is a therapeutic challenge. Aminolevulinic acid-photodynamic therapy (ALA-PDT) has recently been reported to show high curative rates, but there has been relatively little research on this in Korea. OBJECTIVE: The purpose of this study is to evaluate the efficacy and side effects of ALA-PDT with using a light emitting diode (LED) device and 20% 5-aminolevulinic acid for the treatment of recalcitrant hand and foot warts. METHODS: One hundred four warts from 19 patients were selected and then treated with PDT using 20% ALA and a 633-nm LED device until all the lesions had cleared. The light dose was 90~120 J/cm2. RESULTS: The mean number of treatment sessions was 9.1; those for the foot warts and hand warts were 11.2 and 6.5, respectively. After the treatment sessions, a complete response was seen for 55 of 104 warts (52.9%), a partial response-good was seen for 21 of 104 warts (20.2%), a partial response-poor was seen for 18 of 104 warts (17.3%), and no response was seen for 10 of 104 (9.6%). All the patients reported pain during the treatment and 11 patients (57.9%) also had pain at 24 hours after treatment. Post-inflammatory hyperpigmentation occurred in 4 of 19 patients (21.1%). CONCLUSION: ALA-PDT can be a non-invasive and effective treatment modality for recalcitrant hand and foot warts.
