Intralesional Recombinant Alpha-2a Interferon for the Treatment of Patients With Verruca.
10.5021/ad.2000.12.3.155
- Author:
Seung Won AHN
;
Seong Joon SEO
;
Chang Kwun HONG
- Publication Type:Case Report
- Keywords:
Interferon alpha-2a;
Intralesional therapy;
Verruca
- MeSH:
Blister;
Humans;
Incidence;
Injections, Intralesional;
Interferon-alpha;
Interferons*;
Leukemia, Hairy Cell;
Recurrence;
Sarcoma, Kaposi;
Warts*
- From:Annals of Dermatology
2000;12(3):155-159
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Interferon alpha-2a has already been shown to be effective in clinical use of virus-originated diseases such as hairy cell leukemia, condyloma acuminatum, and AIDS-related Kaposi's sarcoma. The use of recombinant alpha-interferon may allow common warts to be treated relatively atraumatically and with less incidence of recurrence. OBJECTIVE: We tried to determine the safety and effectiveness of intralesional injections of recombinant alpha-2a interferon in the treatment of patients with common warts. METHODS: A single wart on each patient was weekly injected with 0.75 to 1.5×10(5) IU/25mm2 of interferon for 8 weeks, and the response to treatment was followed up-to 6 months. RESULTS: Clearing of the treated wart at the end of treatment occurred in 5(71%) out of 7 patients and the rest showed no improvement. With evaluation for relapses up-to 6 months after treatment, warts relapsed in 2(40%) out of 5 patients. Therefore, 3(43%) out of 7 patients were completely free of warts 6 months after treatment. CONCLUSION: Intralesional recombinant interferon alpha-2a has a limited therapeutic effect, but may be considered as a therapeutic modality of recalcitrant verruca or when it can be anticipated that destructive techniques or blistering agents will not be tolerated.
