Development and Persistence of Kindling Phenomenon after Injections of Pentylenetetrazol in Rats.
- Author:
Seung Hwan LEE
1
;
Sang Doe YI
;
Young Choon PARK
Author Information
1. Department of Neurology, Keimyung University School of Medicine, Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Epilepsy, Generalized;
Forelimb;
Linear Models;
Models, Animal;
Neck;
Pentylenetetrazole*;
Rats*;
Seizures
- From:Journal of the Korean Neurological Association
1994;12(3):375-381
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The development of pentylenetetrazol (PTZ) kindling has been controversial, authors confirmed the development of kindling phenomenon in experimental rats following every second or third day intraperitoneal administration of PTZ(20-25mg/kg) to experimental rats and same amount of saline to control rats. The developmental stage of motor seizure could be categorized into five stages (stage I; clonic seizure of face and neck, stage II; clonic seizure of face, neck and forelimbs, stage III; clonic seizure of forelimbs and body with brief rearing, stage IV; falling and generalized clonic seizure, stage V; falling and generalized tonic-clonic seizure with tonic extension of hindlimbs). Linear regression analysis showed that the stages of motor seizure were increased with the number of PTZ injections (Y=0.1361X + 0.1943, p < 0.05). The persistence of kindling state was also observed after a 5-months pause of PTZ injection. This study suggested that PTZ kindling model in rats could be a good animal model of generalized epilepsy.
