Expression of the ATP-gated P2X7 Receptor on M Cells and Its Modulating Role in the Mucosal Immune Environment.

Author: Sae Hae KIM ¹ ; Ha Yan LEE ; Yong Suk JANG
Author Information

1. Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju 561-756, Korea. yongsuk@jbnu.ac.kr
Publication Type:Original Article
Keywords: Adjuvant; Immune modulation; M cells; Mucosal immunity; P2X7 receptor
MeSH: Adenosine Triphosphate; Epithelial Cells; Fatty Acids, Volatile; Gastrointestinal Tract; Immunity, Mucosal; Peyer's Patches; Phenobarbital; Receptors, Purinergic P2X7*
From:Immune Network 2015;15(1):44-49
CountryRepublic of Korea
Language:English
Abstract: Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by microbe-derived molecules such as ATP and short-chain fatty acids. In this study, we undertook to characterize the expression of the ATP-gated P2X7 receptor (P2X7R) on M cells and its role in gastrointestinal mucosal immune regulation because it was poorly characterized in Peyer's patches, although purinergic signaling via P2X7R and luminal ATP have been considered to play an important role in the gastrointestinal tract. Here, we present the first report on the expression of P2X7R on M cells and characterize the role of P2X7R in immune enhancement by ATP or LL-37.